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Combination of in Vitro Caco-2 and Aqueous Solubility Screens with in Silico Physiological Modelling for the Prediction of Human Intestinal Absorption in Early Drug Discovery


Commercial drug discovery is a process of design, optimization and selection of candidate compounds with bothappropriate pharmacological activity and favourable absorption, distribution, metabolism and elimination (ADME)properties.

With the increasing application of high-throughput assays for the determination of the in vitro ADME properties ofcompounds in lead identification and optimization, there is a growing need for efficient and cost-effective methods for interpreting theresulting data to enable well-informed selection to be made for compound progression.