Communicating Drug Discovery Data Efficiently and Effectively
Poster Feb 01, 2007
Jonathan Davies and Andrew Lemon
Drug discovery generates vast amounts of multidisciplinary data which needs to be captured, consistently organized and shared effectively across an organization.
In this poster, we present IDBS’ ActivityBase™ — a single, integrated framework that brings together biological and chemical information. The software integrates with Oracle®, the industry standard relational database and familiar Microsoft® applications such as Word and Excel.
With all discovery data in one system, the communication of information between scientists is simplified — enabling better, faster decisions — and the need for IT support to integrate disparate systems is eliminated.
IDBS is also pioneering software to predict drug efficacy and safety based on pre-clinical data, complementing the scientific expertise of researchers. By predicting potential problems with compounds earlier in the discovery process, costs are cut and efficiency is boosted.
Despite the developments in conventional PCR, the complexity of multiplex Real Time PCR is still limited due to the lack of sufficient detection channels. To achieve high-end multiplexing capacity on standard Real Time PCR machines, Anapa Biotech has developed the MeltPlex® technology (see box on right).READ MORE
Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes. The majority of these are located in the intergenic or intragenic regions suggesting that the implicated variants may alter chromatin conformation. This, in turn, is likely to influence the expression of nearby or more remotely located genes to alter beta cell function. At present, however, detailed molecular and functional analyses are still lacking for most of these variants. We recently analysed one of these loci and mapped five causal variants in an islet-specific enhancer cluster within the STARD10 gene locus. Here, we aimed to understand how these causal variants influence b-cell function by alteration of the chromatin structure of enhancer clusterREAD MORE
The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are closely related transcription factors that regulate the expression of phase I (cytochrome P450s), phase II metabolizing enzymes and transporter genes in response to xenobiotics, including prescription drugs.READ MORE
International Conference on Clinical Trials & Pharmacovigilance
Feb 28 - Mar 01, 2019