Deciphering Regulatory Mechanisms in M. xanthus Using IsotopicRatio Outlier Analysis (IROA) for Metabolome-wide Quantitation
Poster Jun 15, 2014
Daniel Krug 1,2, Carsten Volz 1, Aiko Barsch 3, Chris Beecher 4, Felice de Jong 4, Rolf Müller 1,2
Myxobacteria are an important source of natural products often exhibiting potent biological activity and unusual modes-of-action . Their genomes - among the largest in prokaryotes - harbour intriguing numbers of secondary metabolite biosynthetic pathways, whereas the small-molecule products for many of these have yet to be discovered . Myxobacteria also devote an exceptionally high proportion of their genetic capacity to regulation, as exemplified by the genome of the model strain Myxococcus xanthus DK1622. Deciphering complex myxobacterial regulatory networks improves our ability to manipulate natural product yields and can facilitate the discovery of novel metabolites. Here, we present a comprehensive metabolomics study using comparative LC-hrMS profiling and IROA to quantify small-molecule readouts in response to induced overexpression of a transcriptional antiterminator in DK1622.
Histone Deacetylase 6 (HDAC6) As A Therapeutic Target in Chronic Lymphocytic LeukemiaPoster
This study investigates the role of histone deacetylase 6 (HDAC6) in chronic lymphocytic leukemia and establishes it as a novel therapeutic target for the treatment of this disease.READ MORE
Inhibition of The Auto-inflammation Suppressor Protein ISG15 Triggers Preeclampsia by Blocking Trophoblast Migration and InvasionPoster
In summary, ISG15 expression levels are crucial for trophoblast morphology and function (migration/invasion). By blocking trophoblast invasion, reduced ISG15 levels could contribute to impaired spiral artery transformation that reduces utero-placental blood flow in preeclampsia. Thus, agents inducing ISG15 expression are likely to be therapeutic in preeclampsia.