Depression, Anxiety and Apathy in Young-Onset and Atypical Dementia: A systematic review
Poster May 25, 2018
Credit: Collins et al. UCL
Jessica D, Collins, Susie M.D. Henley, Aida Suarez-Gonzalez
Depression, anxiety and apathy are among the most frequent neuropsychiatric symptoms (NS) in typical Alzheimer’s disease, and impact quality of life, risk of institutionalisation, and caregiver burden. However, prevalence in atypical and young-onset phenotypes remains unknown.
This study aims to examine the body of empirical studies investigating the prevalence of depression, anxiety, and apathy in atypical and young-onset dementia.
Spinal muscular atrophy (SMA) is an inheritable cause of infant mortality that is characterized by the loss of lower motor neurons and skeletal muscle atrophy. The degeneration of motor neurons is caused by insufficient levels of survival motor neuron (SMN) protein, which is encoded by two nearly identical genes SMN1 and SMN2. Most cases of SMA harbour homozygous deletions of the SMN1 gene and retain at least one copy of SMN2.READ MORE
In order to generate a robust protocol for MEA recording on hiPSC- derived neurons, we evaluated several conditions, which could affect culture performance (1.neuron seeding density; 2.seeding medium; 3.astrocyt eco-culture). These conditions were evaluated with BrainXell’s hiPSC-derived spinal motor neurons, cortical glutamatergic neurons and mixed cortical neurons.READ MORE