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Designing a microarray sensor platform for multiplexed transcriptional library
Poster

Designing a microarray sensor platform for multiplexed transcriptional library

Designing a microarray sensor platform for multiplexed transcriptional library
Poster

Designing a microarray sensor platform for multiplexed transcriptional library

Intracellular signalling is achieved through complex networks of pathways that ultimately control transcription factor (TF) activity. Deconvoluting such complexity requires a systems level approach. To enable this we have constructed a library of plasmids carrying a TF binding site upstream of a unique reporter sequence. We have designed and optimized an array based readout, which is sensitive, robust and reproducible, to quantify TF derived dynamic changes within cells.

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