Developing a digital histopathology platform to support an international diabetes biobank
Poster Oct 20, 2014
Sucaet Yves,. Smeets Silke, Waelput Wim, In’t Veld P.eter
Biobanks are a novel application field for digital pathology. The Brussels Free University (VUB) and its teaching hospital UZ Brussel, together with the Belgian Diabetes Registry have developed one of the world’s largest biobanks in the domain of type 1 diabetes. It contains >100.000 blood/DNA samples from patients with type 1 diabetes and their family members in addition to > 4.000 tissue samples from both diabetic and normal pancreas. A digital histopathology platform was deployed to facilitate access to the tissue collection and promote basic and clinical research.
Profiling Personal Air Pollutant Exposures Using a Wearable Non-Selective Passive WristbandPoster
Characterizing cumulative exposure to air pollutant mixtures is a critical step in understanding disease development. The Fresh Air wristband was tested as a personal exposure assessment tool with promising results.READ MORE
Characterization of a Type 2 diabetes-associated islet-specific enhancer cluster in STARD10 by genome editing of EndoC-βH1 cellsPoster
Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes. The majority of these are located in the intergenic or intragenic regions suggesting that the implicated variants may alter chromatin conformation. This, in turn, is likely to influence the expression of nearby or more remotely located genes to alter beta cell function. At present, however, detailed molecular and functional analyses are still lacking for most of these variants. We recently analysed one of these loci and mapped five causal variants in an islet-specific enhancer cluster within the STARD10 gene locus. Here, we aimed to understand how these causal variants influence b-cell function by alteration of the chromatin structure of enhancer clusterREAD MORE
Psychiatric Risk Gene Cacna1c and Early Life Stress: Potential Gene-Environment interactions?Poster
Early life stress (ELS) is highly associated with development of psychopathology
and mood disorders in adulthood. Genetic studies have identified variation in the gene calcium voltage-gated channel subunit alpha1C (CACNA1C) to increase risk for several psychiatric disorders. This poster assessed the expression of Cacna1c following prepubertal stress.
15th International Conference and Exhibition on Metabolomics & Systems
Apr 29 - Apr 30, 2019