Development of an Analytical Data Management System (ADMS) to Accelerate the Selection of a Suitable API Form Through Salt and Polymorph Screening

Abstract

In this work, we discuss the acceleration of the preformulation process through the use of modern software systems. The data system discussed can read, process, store, retrieve, visualize and report a wide variety of data type—XRD, Raman, HPLC, NMR, TGA, DSC, chemical structures, properties and images—in a centralized and homogeneous way. A pilot study at a pharmaceutical company demonstrated possible time savings between 20% and 80% at various points in the preformulation workflow.