Differences in the Neurophysiology of Infants with Down Syndrome May Predict Protective/Risk Markers for Subsequent Alzheimer’s Disease
Poster Feb 01, 2016
Esha Massand1,2, Hana D’Souza1,2, George Ball1,2, Maria Eriksson1, Charlotte Dennison1, Joanna Ball1 & Annette Karmiloff-Smith1,2
Most individuals with DS: AD brain pathology by middle age but not all get dementia
Amyloid precursor protein (APP) gene on Hsa21 over-expressed from infancy onwards
Signs of amyloid plaque build-up already present in some infants at 20 months (Gyure et al., 2011).
Still not understood why some do/don’t go on to develop AD dementia
Only way to fully understand phenotypic endpoint at neural, cognitive or behavioural levels: trace it back to its developmental origins (Karmiloff-Smith 1998)