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Poster

Differences in the Neurophysiology of Infants with Down Syndrome May Predict Protective/Risk Markers for Subsequent Alzheimer’s Disease

Rectangle Image
Poster

Differences in the Neurophysiology of Infants with Down Syndrome May Predict Protective/Risk Markers for Subsequent Alzheimer’s Disease

Background;

Most individuals with DS: AD brain pathology by middle age but not all get dementia

Amyloid precursor protein (APP) gene on Hsa21 over-expressed from infancy onwards

Signs of amyloid plaque build-up already present in some infants at 20 months (Gyure et al., 2011).

Still not understood why some do/don’t go on to develop AD dementia

Only way to fully understand phenotypic endpoint at neural, cognitive or behavioural levels: trace it back to its developmental origins (Karmiloff-Smith 1998)
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