Early Immunogenicity Risk Mitigation
Poster Sep 10, 2014
Chloé Ackaert, Brecht Hoedemaekers, Sofie Pattijn and Philippe Stas
The ability of a drug candidate to induce an unwanted immune response can be a significant hurdle during drug development and a reason for product failures. Unwanted immunogenicity can cause loss of efficacy, altered pharmacodynamics and stability problems.
Implementing early immunogenicity assessment strategies using tools like in silico T cell epitope prediction and in vitro T cell assays can contribute significantly to the successful outcome of drug development programs and reduce the number of product failures.
Screening of ALDH2 Interactome by Combined Immunoprecipitation and Mass SpectrometryPoster
ALDH2 may have an unidentified protein interaction network, which would help elucidate its importance in various cellular functions. The combination of immunoprecipitation and mass spectrometry will give us insights that could not be easily attained otherwise.READ MORE
Nitrogen metabolism in Mycobacterium tuberculosis: a systems-based approachPoster
Previous studies suggested that Mycobacterium tuberculosis obtains nitrogen from a diverse range of intracellular nutrients including amino acids. Here, we use a novel system’s based three-pronged approach to define pathways for uptake and assimilation of nitrogen.READ MORE
Cerebral Malaria Insights: Pathogenesis, Host Parasite Interactions including Host ResistancePoster
Cerebral malaria is a dreadful disease transmitted by mosquito. The major preventive approach is focused more in vector control than development of anti-malarial drug. The purpose of this presentation is to analyze different aspects of disease manifestations including clinical symptoms and pathogenesis in the context of mosquito borne infections in different geographical regions of the world.READ MORE
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World Congress on Advanced Structural and Molecular Biology 2018
Aug 22 - Aug 23, 2018
Asia Pacific Congress on Probiotics, Prebiotics and Nutrition
Oct 15 - Oct 16, 2018