Efficacy of Gene Therapy in Restoring Vision in Leber's Congenital Amaurosis

Poster   Nov 18, 2014

 
Efficacy of Gene Therapy in Restoring Vision in Leber's Congenital Amaurosis
 
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Elizabeth O'Donnell

 
 

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License

 
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Early life stress (ELS) is highly associated with development of psychopathology
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Angioimmunoblastic T-cell lymphoma (AITL) is a common type of peripheral T-cell lymphoma. AITL can be missed until lymphadenopathy develops in patients initially presenting with skin lesions, as skin biopsy may lack conclusive findings. Our case highlights the extranodal presentation of AITL with cutaneous lesions displaying the TFH phenotype.

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The Role of K13 in Artemisinin Resistance

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Plasmodium falciparum is evolving resistance to Artemisinin Combination Therapy. The gene with the strongest association with resistance is K13. K13 is an ortholog of the well characterized transcriptional regulator Keap1. In this work we transcriptionally characterized a mutant with a transposon inserted in the K13 promoter region which results in dysregulation of K13 at 2 points of the intraerythrocytic cycle of the life-cycle to identify the processes regulated by K13.

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