Enhancement of proliferation in a novel rat hepatocyte co-culture model after mitogenic stimulation
Poster Mar 13, 2012
Susan Hester, Michael A. McVay, Oyinade Adefuye, Alan Tennant, and Salman Khetani
Primary mouse and rat hepatocyte cultures have long been the gold standard for assessment of cellular changes associated with chemical exposure. While helpful for assessing proliferative and apoptotic responses in vitro, these cultures have limitations due to loss of cells beyond 48hrs incubation. Rat HepatoPac™ was used to extend the culture time beyond 3 days and coupled with downstream quantitative high content imaging (HCI) technology for a more accurate assessment of the cell proliferative response following mitogenic stimulation.
Extracorporeal shockwave therapy accelerates motor axon regeneration despite a phenotypically mismatched environmentPoster
A femoral nerve defect model was adapted for the evaluation of proregenerative effects of extracorporeal shockwave therapy (ESWT). Functional evaluation, histology and qRT-PCR data show differences between sensory and motor-derived nerve transplants and a pro-regenerative effect of ESWT. These data provide evidence for the clinical application of ESWT after autologous nerve transplantation as a novel non-invasive method.READ MORE
Histone Deacetylase 6 (HDAC6) As A Therapeutic Target in Chronic Lymphocytic LeukemiaPoster
This study investigates the role of histone deacetylase 6 (HDAC6) in chronic lymphocytic leukemia and establishes it as a novel therapeutic target for the treatment of this disease.READ MORE