Evidence for Integrating Point of Care Diagnostics as an Integral Part of Primary Healthcare in South African Rural Communities: A People-centred Health System-strengthening Approach
Poster Sep 19, 2014
T.P. Mashamba-Thompson, N. Moodley, M.M. Moshabela
Background: It has been estimated that the deployment of new POC diagnostics could prevent more than 1.2 million deaths in the developing world.
Objective: We conducted a scoping review on the impact of point of care testing (POCT) compared to laboratory tests for enabling the following patient centred outcomes in resource-limited settings.
Methods: A detailed search on NCBI, WED of Science and EBSCOhost for relevant publications from inception to current, combined into phrases including Boolean (AND, OR) using a keyword searches with the terms “rural communities”,“ point of care testing”, “ early diagnosis ” , “ improved healthcare outcome” and “access to healthcare”.
Results: 14 studies met the inclusion and quality criteria. There appears to be growing interest in the integration of POCT for management of HIV, detection of HIV co-infections. However, evidence to date, does not adequately address other components that are crucial to the sustainability of POCT services such as: accessibility; availability; acceptability; reliability of POC diagnostics in resource limited settings as well knowledge and skill level of current POCT amongst all stakeholders.
Conclusion: Further evaluation of current POC diagnostics is necessary prior to adoption and scale up of POCT in South Africa’s resource-limited settings.
When there is a need to quickly analyze samples using a number of different PCR assays, it is likely that optimal conditions for each assay will not be the same. First, different assays often will require different annealing temperatures for their primers. In addition, amplicons may be designed to be of different lengths and therefore require varying durations of the extension step.READ MORE