Exploring the Ionization Space in Traditional Electron Ionization with High Resolution GC=TOFMS for a Variety of Compound Classes
Poster Jun 19, 2014
Jonathan D. Byer, David Alonso, Joe Binkley, Charles Lyle, and Jeff Patrick
Recommended source conditions for contributing electron ionization (EI) mass spectra to commercial libraries are ionization energy of 70 eV and an ion source temperature of 200°C. However, spectral quality is affected by other source parameters, such as filament emission current and differences in instrument manufacturers’ source design.
The primary objective of this study was to optimize LECO’s GC-HRT EI source parameters to enhance the molecular ion of thermally labile compounds like linear alkanes, fatty acid methyl esters, and pesticides.
The secondary objective was to optimize the EI source for other classes of compounds to achieve a global optimum for non-targeted analysis, since this is the primary utility of most time-of-flight mass spectrometry (TOFMS) systems.
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We developed an automated sample preparation protocol based on a robotic platform PAL RTC (CTC Analytics AG, Zwingen Switzerland), which represent a modified Bligh and Dyer method producing samples for both hydrophilic metabolomics using GC-MS and lipidomics using SFC-MS simultaneously.READ MORE