Finite Element Modelling for the Optimization of Temperature Control in Lab-on-a-Chip Devices
Poster Mar 17, 2016
T. Pardy(a,b); T. Rang(a); I. Tulp(b)
Some of the assays actively developed in a Lab-on-a-Chip format require temperature control, mostly heating to a specified range for the duration of the assay. In a highly portable system with limited power supply, heating microliters of liquids poses technical challenges, which may be costly to overcome solely by experimental means. The way computer-aided design helps in rapid prototyping, so does finite element modelling help in validating the functionality of these prototypes in silico, saving time and costs. The model we present was developed for the geometric optimization of Lab-on-a-Chip devices and tested for experimental setups emulating the targeted device format. The model is presented for multiple temperature control scenarios, i.e. heaters and device geometries.
The immune system is a striking example of an integrated information system, engaged in coordinated host-protective activities. Organs-on-chip approach (OOC) models allow the direct simultaneous observation of hundreds of different cells, moving, interacting and responding to signals coming from the microenvironment nearby, that give access to a number of parameters describing the system that must be properly measured and elaborated.READ MORE