Fragmentation Trees for Automated de novo Interpretation of Impure Electron Ionization Spectra from Gas Chromatographic Complex Mixture Analysis—Chemical Deconvolution
Poster Jun 12, 2015
Kevin Siek, Vasily Makarov, Viatcheslav Artaev, Dmitry Mazur, Albert T. Lebedev
-Impure spectra contain signals from multiple analytes or signals unrelated to the main analyte, due to propinquitous coelution that confounds purely mathematical de-coelution. Some such spectra are expected in complex sample analysis.
-Impure spectra may impede manual or automated interpretation and beget false assignments or other failures.
-Chemical information within high-resolution spectra can assist mathematical de-coelution and facilitate analyte identification.
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Previous studies suggested that Mycobacterium tuberculosis obtains nitrogen from a diverse range of intracellular nutrients including amino acids. Here, we use a novel system’s based three-pronged approach to define pathways for uptake and assimilation of nitrogen.READ MORE
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Role of Elevated Airway Glucose (and Other Biochemicals) in Bacterial InfectionsPoster
Bacteria that live in the airways need something to eat: they mainly use host derived biochemicals, for example glucose. When levels of airway biochemicals are dysregulated, bacterial colonisation increases, enabling infection. We investigated how changes in airway glucose effect bacterial infection.READ MORE