Fully Automated LC-MS/MS-based Determination of Bosentanand its Metabolites in Dried Blood Spots using the SCAP™ DBS System
Poster Dec 07, 2010
Mirko Glinski, Norbert Ganz, Jasper Dingemanse, Laurent Nicolas and Werner Döbelin
The advantages of DBS are:
• Only low amount (25 μL) of test material needed
• Minimal sample processing needed
• Sample storage and shipment at ambient temperature possible
However automation of the DBS workflow is needed to enable a through put that can compete with conventional plasma analysis. This poster details how the SCAP™ DBS System allows fully-automated DBS analysis via LC-MS/MS without need of time-consuming spot punching and manual extraction.