High-throughput analysis of protein formulations by DLS
Poster Apr 07, 2014
Sophia Kenrick and Daniel Some
High-Throughput Screening by Dynamic Light Scattering (HTS-DLS) is a versatile tool for characterizing various aspects of protein stability in parallel. High-throughput analysis by the DynaPro DLS plate reader provides parallel analysis of multiple stability-indicating parameters for screening of developability and optimal formulations.
We found a distinct subpopulation of Tregs within BMSCs. Tregs and BMSCs in co-culture conferred neuroprotection that varied in a dose-dependent manner. Tregs minimized stem cell production of IL-6, a pro-inflammatory cytokine, and inhibited BMSC secretion of FGF-beta, a cytokine related to BMSC proliferation and differentiation. The ratio of Tregs found natively in BMSCs is optimally adapted to provide the maximum neuroprotective benefit of stem cell treatment after ischemic stroke.READ MORE