Identification of Novel BACE-1 Inhibitors through an Advanced Structure-Based Virtual Screening Protocol
Poster Apr 04, 2012
Puneet Kacker, Angela De Simone, Matteo Masetti, Giovanni Bottegoni, Vincenza Andrisano, Andrea Cavalli
BACE-1 is considered a challenging target for two main reasons: (1) the protonation state of the catalytic dyad varies depending on the nature of the interacting molecule, and (2) the protein binding site is extremely flexible. Here, we propose a virtual ligand screening (VLS) protocol that addresses these two issues simultaneously.
Application of Solid Phase Micro Extraction (SPME) and On‐Fiber Derivatization to Detect Precursors of Biomolecules in the study of Proto‐metabolismPoster
In the studies of origins of life, plausible synthetic reaction pathways to form biological relevant molecules, or building blocks of proto‐bilayer lipids, protein, RNA, and DNA in the primitive environment have been investigated intensively.READ MORE
A Tissue-based Proteomic Study of VEGFR2 in Human Term PlacentasPoster
VEGFR2 is the main regulator of placental angiogenesis and at term is localized in endothelial cells (EC) of the villous vasculature. VEGFR2 immunoprecipitation (IP) of membrane proteins, extracted from the fetal compartment, isolated 30 proteins that were identified by proteomic analysis.READ MORE