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In Vitro Approaches To Risk Assess Chemical-Mediated Changes in Thyroid Function

The hypothalamic-pituitary-thyroid axis (HPT axis) is conserved across vertebrate evolution. Perturbation of thyroid hormone homeostasis (THH) can lead to adverse effects in thyroid function affecting growth, metabolism and cognitive function. In utero, appropriate thyroid hormone concentrations are vital for normal nervous system development and a variety of experimental approaches are required to thoroughly investigate the effects of chemicals on thyroid function.

Download the poster to discover the experimental approaches that have been developed to help understand the effects of chemicals on thyroid function:

  • Inhibition of rat and human deiodinase 1, 2 or 3
  • Sodium/iodide symporter inhibition (NIS) (rat)
  • TPO inhibition (multiple species)
  • In vivo and in vitro hepatic thyroid hormone metabolism (multiple species)