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In vitro Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells Towards the Osteoblast Lineage. A Model to Study the Effects of Cancer Cells on Bone Formation

Abstract

This poster describes an in vitro model of DAG-induced osteogenic differentiation of bone marrow mesenchymal stem using various osteoblastic markers. The data indicates the need to use MSC during the second and third cell passages. The passaged cells may lose their ability of differentiation into osteoblast. Human MSC should constitute a useful in vitro tool to the effects of osteotropic cancer cells on osteoblast differentiation and to better understand the inhibition of normal formation during the process of tumor-induced osteolysis.
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