Increasing the Generalization Capability of Biomarkers Through Systems Biology Malaria Vaccines Case Study
Poster Feb 04, 2015
Simón Perera del Rosario 1, Raquel Valls 1, Gemma Moncunill 2, Teresa Sardón 1, Carlota Dobaño 2, José Manuel Mas 1
Finding biomarker combinations is a difficult task. As a problem with a large number of solutions, they usually lack generalization power. One example is the fact that a surrogate biomarker of immunity has been difficult to achieve for malaria and other complex diseases through classical immunological assays. Within the context of SysMalVac, a project partially funded by the European Seventh Framework Programme (FP7) , Anaxomics proposed to use Systems Biology in order to analyse two malaria vaccination models (the RTS,S vaccine and the CPS immunization strategy) in order to identify combinatorial biomarkers of protection. The aim of the project is to design a tool able to predict whether a person will be protected from malaria after vaccination. The prediction is achieved through the development of mathematical models including newly generated cellular transcriptome profiles, immunological read-outs and transcriptomic results from both trials, and experimental data obtained from non-human primates. This analytical tool will not also predict each individual’s protection, but will also allow identifying a biomarker signature indicative of protection to malaria.
 The SysMalVac Consortium. SysMalVac. 2013 [cited 2014 11 July 2014]; Available from: http://www.sysmalvac.eu/
Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes. The majority of these are located in the intergenic or intragenic regions suggesting that the implicated variants may alter chromatin conformation. This, in turn, is likely to influence the expression of nearby or more remotely located genes to alter beta cell function. At present, however, detailed molecular and functional analyses are still lacking for most of these variants. We recently analysed one of these loci and mapped five causal variants in an islet-specific enhancer cluster within the STARD10 gene locus. Here, we aimed to understand how these causal variants influence b-cell function by alteration of the chromatin structure of enhancer clusterREAD MORE
This abstract discusses three cases of pediatric heart transplant patients who suffered from parvovirus (B19) infection. Of these patients, two ( B & C) responded well to standard intravenous Ig therapy. Patient A however, did not respond to standard treatment and was begun on subcutaneous Ig, which effectively diminished his viral load. Thus, subcutaneous Ig infusions might serve as a second line treatment for transplant patients with parvovirus who do not respond well to the standard approach.READ MORE