Integrating compound storage into automated laboratory workflows
Poster Jun 12, 2013
James Craven, Simon Tullett
The demand for automated storage facilities for a wide range of compounds, small molecules, fragments and RNAi libraries and biologics is rapidly increasing as sample libraries expand across a range of industries and applications.
TTP Labtech’s comPOUND® offers robust storage for chemical and biological samples, which has been successfully employed for over a decade. comPOUND modules have been relied on by large pharmaceutical companies, academic research facilities and hospitals, as well as small biotech and contract research organisations who are committed to providing rapid throughput and delivery of high quality samples.
There has been considerable investment in automated storage facilities for compound and biological libraries, alongside automated instrumentation for liquid handling, HTS, HCS and analysis. Despite this, the process of sample transfer between such instrumentation still relies on manual effort. Often samples need to be transferred over considerable distances between storage rooms or even laboratories. On arrival, scientists need to prepare samples and place tubes or microplates into automated liquid handling platforms or assay instrumentation.
This poster discusses the benefits of comPOUND for automated sample storage and delivery. TTP Labtech’s pneumatic transport technology, lab2lab, enables integration of these stores with other instrumentation into managed, fully automated workflows - from sample storage to liquid handling, assay set-up, experimental analysis and QC. This allows the scientist to concentrate on research and data analysis.
We found a distinct subpopulation of Tregs within BMSCs. Tregs and BMSCs in co-culture conferred neuroprotection that varied in a dose-dependent manner. Tregs minimized stem cell production of IL-6, a pro-inflammatory cytokine, and inhibited BMSC secretion of FGF-beta, a cytokine related to BMSC proliferation and differentiation. The ratio of Tregs found natively in BMSCs is optimally adapted to provide the maximum neuroprotective benefit of stem cell treatment after ischemic stroke.READ MORE
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