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Interfacing Microwave Synthesis with Enabling Technologies in Drug Discovery
Poster

Interfacing Microwave Synthesis with Enabling Technologies in Drug Discovery

Interfacing Microwave Synthesis with Enabling Technologies in Drug Discovery
Poster

Interfacing Microwave Synthesis with Enabling Technologies in Drug Discovery

Introduction

Modern drug discovery steadily relies on high-speed organic synthesis and combinatorial chemistry techniques for the rapid generation of compound libraries. Microwave-assisted organic synthesis in combination with polymer-assisted solution phase (PASP) methods are powerful techniques that are frequently applied in both academia and industry.

Here we report on the rapid synthesis/decoration of privileged heterocyclic scaffolds, namely the dihydropyrimidine (DHPM) scaffold, by applying microwave heating in conjunction with PASP approaches. The use of resin-bound catalysts, reagents and scavengers as well as fluorous reagents in conjunction with microwave heating will be described for amidations, esterifications via a Mitsunobu protocol and N-acylations.
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