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Isolated Limb Infusion as a Limb Salvage Strategy for Locally Advanced Extremity Sarcoma

Poster   Feb 14, 2017

 
Isolated Limb Infusion as a Limb Salvage Strategy for Locally Advanced Extremity Sarcoma
 
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Matthew C. Perez, MD ; John E. Mullinax, MD ; Hidde M. Kroon, MD ; John F. Thompson, MD ; Neel Nath, BS ; Paul J. Mosca, MD, PhD ; Jeffrey M. Farma, MD ; Rajendra Bhati, MD ; Danielle Hardman, BS ; Sean Sileno, BS ; Cristina O’Donoghue, MD ; Syeda Mahrukh Hussnain, Naqvi, MD ; Y. Ann Chen, PhD , Ricardo J. Gonzalez, MD ; Jonathan S. Zager MD

 
 

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License

 
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We show that network analysis of co-localized ions from mass spectrometry imaging data provides a detailed chemo-spatial insight into the metabolic heterogeneity of tumors. Furthermore, module preservation analysis between colorectal cancer patients with and without metastatic recurrence suggests hypotheses on the nature of the different local metabolic pathways.

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Studies have shown that IFI16 acts as an antiviral restriction factor against a number of DNA viruses, by inhibiting viral replication or transcription through epigenetic modifications. However, till date, no specific epigenetic function of IFI16 has been identified. Here, we have discovered that IFI16 recruits two histone methyltransferases on the KSHV episome leading to altered Histone H3K9 methylation, thus regulating its lifecycle.

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