Low Volume Liquid Handling of Organic Solvents for Compound Storage and Dissolution using mosquito
Poster Feb 28, 2008
Gillian Lewis, Tristan Cope, Joby Jenkins, David Gledhill & Rob Lewis
The technology of storing dried microquots is an interesting new idea which aims to reduce very significantly the amount of material – and in particular of intermediate material – wasted in the process of synthesising new compounds. This technology may also benefit drug screening where there is a similar need to conserve material and where there are also concerns of material stability.
mosquito® (TTP LabTech) is a positive displacement liquid handling system capable of pipetting solutions with a high degree of accuracy (to within 5%) and precision (CVs of <10%) in the nanolitre range.
Here, we demonstrate mosquito’s ability to dispense accurately low volumes of organic solvents of low surface tension and to re-dissolve compounds which have been previously dried in storage wells.