Macrocyclic Library with Conformationally Diverse Scaffold: Synthesis and Biology

Poster Oct 21, 2005

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N. Qvit, S. Gazal, H. Reuveni, M. Niv, G. Blum, A. Feldstein, S. Meushar, A. Friedler and C. Gilon

Here we present the SIB concept, based on macrocyclic libraries in which the ring size is varied in gradual manner (conformational diversity). This allows selection of bioactive molecules based on their conformational complementary.

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License

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