Mechanistic Prediction of Volume of Distribution: The Influence of Plasma and Tissue Binding
Drug molecules circulate in plasma either free or bound to plasma proteins such as albumin (acidic drugs), α1-acid glycoprotein (basic drugs), lipoproteins (neutral compounds), etc. The extent of plasma protein binding (PPB) is a key determinant of all subsequent distribution processes including CNS permeation, partitioning into tissues, and elimination.
