Mechanistic Prediction of Volume of Distribution: The Influence of Plasma and Tissue Binding
Poster Dec 07, 2010
Kiril Lanevskij, Remigijus Didziapetris, Pranas Japertas
Drug molecules circulate in plasma either free or bound to plasma proteins such as albumin (acidic drugs), α1-acid glycoprotein (basic drugs), lipoproteins (neutral compounds), etc. The extent of plasma protein binding (PPB) is a key determinant of all subsequent distribution processes including CNS permeation, partitioning into tissues, and elimination.
During early drug discovery, the study of metabolism plays an essential role in determining which drug candidates move forward into development and later stages. As an alternative to traditional Data Dependent Acquisition (DDA), the use of MSE/All Ions Fragmentation (AIF) has become common in metabolite identification workflows for the analysis of metabolic hot spots. Here we present a solution for analysis of MSE/AlF in metID studies.READ MORE