Mesenchymal Stem Cells: Coming of Age?
Poster Jun 16, 2006
Alexandra Stolzing and Andy Scutt
AbstractThe effects of aging on human mesenchymal stem cells, (MSC) were investigated. MSC were isolated from patients of different ages and the different parameters of aging were measured either immediately after isolation or after long-term cultivation in vitro. Markers of senescence were investigated, including p21, p53 and beta-galactosidase levels. Antioxidative defense capacity of the MSC were tested together with markers of oxidative damage and antioxidative enzyme activities. Also the changes in differential potential and numbers of MSC were investigated.
Regulatory T-Cells (Tregs) Within Bone Marrow-Derived Stem Cells (BMSCs) Actively Confer Immunomodulatory and Neuroprotective Effects Against StrokePoster
We found a distinct subpopulation of Tregs within BMSCs. Tregs and BMSCs in co-culture conferred neuroprotection that varied in a dose-dependent manner. Tregs minimized stem cell production of IL-6, a pro-inflammatory cytokine, and inhibited BMSC secretion of FGF-beta, a cytokine related to BMSC proliferation and differentiation. The ratio of Tregs found natively in BMSCs is optimally adapted to provide the maximum neuroprotective benefit of stem cell treatment after ischemic stroke.READ MORE
Quantitative Live-Cell Analysis Using Automated Long-Term ImagingPoster
Here we describe a continuous live-cell assay for determining cell proliferation profiles using the BioSpa Automated Live Cell Imaging System, consisting of BioSpa 8 and Cytation 5.READ MORE
Assessment of Oral LISPRO Treatment in Ameliorating Amyloid and Tau Pathology in Transgenic Alzheimer’s Mice ModelPoster
Ionic co-crystals of lithium salicylate with organic proline (LISPRO) showed better safety and pharmacokinetic profile of lithium in plasma and brain of wild-type and transgenic Alzheimer mice model compared to lithium salts.READ MORE