Microbiological Control in a Stem Cell Bank: Standardisation
Poster Jun 16, 2006
F. Cobo, A. Nieto, R.M. Montes, C. Cadrera, A. Barnie, J.L.Cortes, P. Catalina, L. Gutierrez, R. Lopez and A. Concha
IntroductionThe transplant of cells of human origin is a sector of medicine which shows a high increase and which entails great opportunities for treatment of certain diseases. Stem cell banks should assure the quality, the traceability and the safety of cultures in order to avoid transmission of disease.
We found a distinct subpopulation of Tregs within BMSCs. Tregs and BMSCs in co-culture conferred neuroprotection that varied in a dose-dependent manner. Tregs minimized stem cell production of IL-6, a pro-inflammatory cytokine, and inhibited BMSC secretion of FGF-beta, a cytokine related to BMSC proliferation and differentiation. The ratio of Tregs found natively in BMSCs is optimally adapted to provide the maximum neuroprotective benefit of stem cell treatment after ischemic stroke.READ MORE