Microwave Accelerated Heterogeneous Catalysis – Flow-Through Reactor Concept and Application
Poster Jan 18, 2007
T. Glasnov, K. Mennecke, R. Cecillia, U. Kunz, A. Kirschning and C.O. Kappe,
Flow-through processes in organic synthesis become more important as an enabling technology for a cost effective and convenient method. This requires appropriate reactors with functionalities for organic reactions. In this project noble metal-loaded polymer/carrier reactors able to be operated in a microwave field were investigated.
By application of a microwave field metal sites are heated whereas the polymer/carrier material remains transparent to irradiation. This may lead to hot-spots with higher reactivity which contribute to a more efficient heating and thus to the higher observed reaction rates.
Initial results on catalyst preparation and characterization as well as investigations on the microwave heating process are presented. The field of application covers Pd-catalyzed transfer hydrogenations as well as C-C coupling reactions.
These results support the use of hSC-CM and MEA technology for preclinical assessment of proarrhythmic risk within the proposed CiPA paradigm, and, more generally, demonstrate that automation of the CM-MEA assay can achieve high reliability and throughput for cardiac risk assessment in vitro.READ MORE