Microwave Assisted Synthesis of Substituted 2(1H)-Quinolones as Maxi-K+ Channel Openers

Poster Apr 01, 2006

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Toma Glasnov, Wolfgang Stadlbauer and C. Oliver Kappe

Abstract
Here we present a novel synthetic strategy for synthesis of 4-aryl-2(1H)-quinolone lead compounds for the treatment of male ED. The MW-reaction protocols are high-diversity generating, flexible, amenable to high-speed MAOS, scalable and involve commercially available building blocks. Our approach for making the 4-arylquinolones includes a cyclization step, chlorination/hydrolysis, Suzuki C-C coupling,[8] bromination, and finally a Heck reaction, all under microwave conditions.

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License

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