Microwave-Assisted Three-Component One-Pot Synthesis of Highly Substituted 2-Pyridinones
Poster May 21, 2006
Behrooz H. Yousefi, Nikolay Yu. Gorobets and C. Oliver Kappe
Pyridone and quinolone analogous are known to possess valuable biological activities. The aims of this research were the development of a one-pot multi-component synthesis of 2-pyridinone libraries and the application of controlled microwave heating to gain rapid access to diverse 2-pyridinones utilizing CH-acidic carbonyl compounds 4, DMFDMA 5 and methylene active nitriles.