Modeling Neurodegeneration Using a Human Isogenic System
A Next-Generation Approach to Study Frontotemporal Dementia and Amyotrophic Lateral Sclerosis
Less than 10% of preclinical animal studies are translated to humans, meaning there is a need for better human models of disease for research and drug discovery. Patient-derived induced pluripotent stem cells (iPSCs) enable generation of in vitro models that can recapitulate human disease. However, conventional human iPSC differentiation protocols are often lengthy, inconsistent and difficult to scale.
A new precision cellular reprogramming technology known as optimized inducible overexpression (opti-ox™) aims to solve these problems.
Download this poster to discover new data from a technology that:
- Enables the generation of consistent, defined human iPSC-derived disease models of neurodegeneration within days
- Can be paired with isogenic controls to ensure biological compatibility within experiments
- Generates well characterized disease models with disease-relevant phenotypes