Modular Bench Top Automation
Poster Feb 15, 2012
Paul Held, Dean Mulyk, Lenore Buehrer and Grace Mangialardi
Using the modular ELISA workstation we have automated the assay process steps of an HIV ELISA assay kit. Plates with samples and controls can be loaded on to the system and the user simply presses a button and walks away. This poster will detail specifics of such a system, with automation workflows and details regarding throughput and performance provided.
Quantitative Cell-Based Bioassays for Individual and Combination Immune Checkpoint Immunotherapy TargetsPoster
The human immune system is comprised of a complex network of immune checkpoint receptors that are promising new immunotherapy targets for the treatment of a variety of diseases including cancer and autoimmune-mediated disorders.READ MORE
Reporter Bioassays to Assess Therapeutic Antibodies for Immunotherapy ProgramsPoster
Immunotherapy, also called biologic therapy or biotherapy, stimulates certain parts of the immune system to fight diseases such as cancer. Important drug targets in immunotherapy include: Co-inhibitory receptors, such as PD-1/PD-L1, CTLA-4, LAG3, Tim3; and co-stimulatory receptors, such as GITR, CD40, OX40, 4-1BB.
Current approaches to assaying these targets are cumbersome and variable. Here we offer an improved in vitro bioassay approach.
Modelling CLL cell and T-cell Migration in a Dynamic Circulating Model of CLLPoster
We have recently developed a novel circulating model of chronic lymphocytic leukaemia (CLL) that mimics the transient interactions that take place between circulating lymphocytes and vascular endothelium. Here we show that both normal and malignant lymphocytes actively underwent transendothelial migration.READ MORE