Molecular Abnormalities in Schizophrenia: Neurotransmission, Oxidative Stress, and Apoptosis
Poster Jun 22, 2016
Elizabeth J. Want,1 Hendrik Wesseling, 2 Elaine Holmes, 1 and Sabine Bahn 2
Schizophrenia affects 1% of the world’s population.
• Broad, heterogeneous range of symptoms hinders the effectiveness of current therapies.
• New models reproducing core schizophrenia features are needed to elucidate pathological disease mechanisms, identify biomarkers for improved diagnosis and discover potential novel drug targets.
• A multi-platform approach was employed to analyse distinct brain regions implicated in schizophrenia.
IntelliXtract 2.0: Simplified Intelligent Component Extraction and DetectionPoster
*Simplified detection and Component Extraction algorithm from LC-MS and GC-MS datasets
*New improved algorithm based on ion threads
*Reduced number of parameters to select for analysis
*Reduced false positives leading to reduced analysis time
LC-SWATH/MS Metabolomics Platform with Hyphenation of Extraction for the Analysis of Polar and Non-polar Metabolites in Biological SamplesPoster
Automated robotic sample preparation with hyphenated dual LC-SWATH/MS analysis for lipids and polar metabolites.
Investigating the Effects of Fructose Consumption and Inadequate Copper Intake on Nonalcoholic Fatty Liver DiseasePoster
Metabolomics is a viable method for identifying compounds associated with NAFLD. In this investigation, high-quality data facilitate the identification of key metabolites differentiating normal versus diseased species.READ MORE