Molecular Abnormalities in Schizophrenia: Neurotransmission, Oxidative Stress, and Apoptosis
Poster Jun 22, 2016
Elizabeth J. Want,1 Hendrik Wesseling, 2 Elaine Holmes, 1 and Sabine Bahn 2
Schizophrenia affects 1% of the world’s population.
• Broad, heterogeneous range of symptoms hinders the effectiveness of current therapies.
• New models reproducing core schizophrenia features are needed to elucidate pathological disease mechanisms, identify biomarkers for improved diagnosis and discover potential novel drug targets.
• A multi-platform approach was employed to analyse distinct brain regions implicated in schizophrenia.
LC-SWATH/MS Metabolomics Platform with Hyphenation of Extraction for the Analysis of Polar and Non-polar Metabolites in Biological SamplesPoster
Automated robotic sample preparation with hyphenated dual LC-SWATH/MS analysis for lipids and polar metabolites.
Investigating the Effects of Fructose Consumption and Inadequate Copper Intake on Nonalcoholic Fatty Liver DiseasePoster
Metabolomics is a viable method for identifying compounds associated with NAFLD. In this investigation, high-quality data facilitate the identification of key metabolites differentiating normal versus diseased species.READ MORE
A Tissue-based Proteomic Study of VEGFR2 in Human Term PlacentasPoster
VEGFR2 is the main regulator of placental angiogenesis and at term is localized in endothelial cells (EC) of the villous vasculature. VEGFR2 immunoprecipitation (IP) of membrane proteins, extracted from the fetal compartment, isolated 30 proteins that were identified by proteomic analysis.READ MORE