Molecular Dynamics Simulation Study of Pulmonary Surfactant Interacting With Nanoparticles
Poster Oct 11, 2013
Dipalmitoylphospatidylcholine (DPPC) a phospholipid, is the main component of the lung pulmonary surfactant. Components of pulmonary surfactant including dipalmitoylphosphatidic acid (DPPA), dipalmitoylphosphatidyl ethanolamine (DPPE), dimyristoylphospatidylcholine (DMPC) and possibly lung pulmonary surfactant proteins are expected to play a significant role in the biological mechanism of defense against quartz cytotoxicity. Interactions of powder crystalline silica with biological systems cause cell damage, inflammation, and apoptosis. Unfortunately, mechanisms involved in these diseases are still unknown. Currently, molecular dynamics (MD) simulation of phospholipid bilayer are widely used to study the physicochemical properties of pure bilayers, composite bilayers, lipid rafts, cellular processes such as signaling and transport, permeation of water. Silica dust particles in the form of quartz (but not kaolin) have been hypothesized to promote pulmonary diseases such as silicosis. An exact mechanism of silica cytotoxicity at the molecular level is still unknown. It is known that silanol groups on crystalline silica are lethal while amorphous silica and silica in phyllosilicates (e.g., kaolinite) cause virtually no long-term adverse effects. Our 5ns MD simulation studies using NAMD of lipid bilayers supported on alpha-quartz (nanoparticles) and kaolinite with explicit water molecules will be presented to understand the physiochemical effects of nanoparticles on pulmonary surfactant.
Identifying Asthma-related Health Disparities Among Children in Hillsborough CountyPoster
Our project was to identify a geographic area demonstrating need for asthma interventions. By identifying different factors such as air quality, prevalence, asthma related hospitalizations and emergency department visits, we created a tool to identify and prioritize areas that could benefit from interventions like patient education and certification as an Asthma-Friendly School.
From Farm to Landfill: Results of a Campus-Community Awareness Event to Promote Sustainable Food SystemsPoster
In April 2017, a campus-community event (N=42 participants) was held to promote sustainable food systems by educating participants about concepts ranging from food production to nutrition and food waste management. This poster discusses the resulting increased awareness and knowledge of a our local food system among participants, which can be fostered through educational events that combine opportunities for research, teaching, and practice.READ MORE
Environmental Exposures and Inflammatory Bowel Disease in ChildhoodPoster
Inflammatory bowel diseases (IBD) often present in adolescence and affect >1.4 million persons in the US. Environmental exposures, notably air pollution and weather, have been suggested to contribute to IBD disease activity. Our goal was to evaluate relationships between environmental exposures and the prevalence and disease activity of pediatric IBD using novel data sources that take into account geographic location.READ MORE