Mortality after Motor Vehicle Accidents; A Forensic and Pathological Analysis from a Regional Collaboration
Poster May 06, 2015
Mr G Bessant, Mr N Misra, Mr J Hollingsworth
We have formed a collaborative approach to data collection between Merseyside major trauma collaboration, Merseyside police force, and the regional coroner's offices with the aim of identifying areas within the Haddon matrix for targeted local intervention.
Characterization of a Type 2 diabetes-associated islet-specific enhancer cluster in STARD10 by genome editing of EndoC-βH1 cellsPoster
Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes. The majority of these are located in the intergenic or intragenic regions suggesting that the implicated variants may alter chromatin conformation. This, in turn, is likely to influence the expression of nearby or more remotely located genes to alter beta cell function. At present, however, detailed molecular and functional analyses are still lacking for most of these variants. We recently analysed one of these loci and mapped five causal variants in an islet-specific enhancer cluster within the STARD10 gene locus. Here, we aimed to understand how these causal variants influence b-cell function by alteration of the chromatin structure of enhancer clusterREAD MORE
Psychiatric Risk Gene Cacna1c and Early Life Stress: Potential Gene-Environment interactions?Poster
Early life stress (ELS) is highly associated with development of psychopathology
and mood disorders in adulthood. Genetic studies have identified variation in the gene calcium voltage-gated channel subunit alpha1C (CACNA1C) to increase risk for several psychiatric disorders. This poster assessed the expression of Cacna1c following prepubertal stress.
Idiopathic Pulmonary Fibrosis: The Importance of Multiple-site SamplingPoster
This research project attempts to highlight the importance of sampling from multiple sites of the lungs of patients with Idiopathic Pulmonary Fibrosis. Examining the histopathology of the human lung samples with IPF shows varying levels of fibrosis in different sites of the lung. To ensure an accurate representation of a patient's lungs, it is important to obtain samples from multiple sites on the lobes of the lungs.READ MORE