mosquito® Crystal and mosquito® LCP: fast, reliable automation of protein crystallisation drop set-up
Poster Mar 06, 2013
Joby Jenkins, David Smith
The automation of protein crystallography screening has contributed significantly to the rapid progress of crystallography-based structural biology. Automation offers increased throughput and repeatability. It also offers the ability to accurately dispense smaller volumes of both protein and screen solutions, which saves valuable protein and reduces reagent costs.
Automation of protein crystallisation screening trials requires accurate placement of nanoliter volumes of protein and screen drops, in addition to the reproducible and accurate dispensing of solutions of varying viscosities. This is particularly important for the set-up of the highly viscous lipid mesophases in the Lipidic Cubic Phase (LCP) crystallisation technique for membrane protein crystallisation trials.
This poster describes the features of TTP Labtech’s mosquito® Crystal and mosquito® LCP, showing their ability to address the issues inherent in the automated set-up of protein crystallisation screen trials. An instrument capable of automating both microbatch and vapour diffusion methods of protein crystallography (sitting drop, hanging drop) as well as crystallisation of membrane proteins using the bicelle and LCP methods, without instrument configuration changes, offers significant flexibility for the crystallography laboratory
mosquito Crystal and mosquito LCP offer fast throughput, high precision, unrivalled reproducibility and low volume accuracy.
CiPA Phase 2 Study: validation of an automated microelectrode array (MEA) assay of hiPSC-derived cardiomyocyte electrophysiology for cardiac safety evaluationPoster
These results support the use of hSC-CM and MEA technology for preclinical assessment of proarrhythmic risk within the proposed CiPA paradigm, and, more generally, demonstrate that automation of the CM-MEA assay can achieve high reliability and throughput for cardiac risk assessment in vitro.READ MORE
Extraction of Analytes of Toxicolgical Interest from Plasma with Enhanced Matrix Removal-Lipid MaterialPoster
Extraction of Analytes of Toxicolgical Interest from Plasma with Enhanced Matrix Removal-Lipid (EMR-Lipid) Material.READ MORE
Comments | 0 ADD COMMENT
Orphan Drugs and Rare Diseases Global Congress 2017 USA
Sep 12 - Sep 14, 2017