Neuroprotection by T-Lymphocytes and Stem Cells After Ischemic Stroke
Poster Feb 13, 2017
Elliot Neal, MS; Sandra Acosta, MS PhD; Yuji Kaneko, PhD; Cesario Borlongan, MA PhD
Stroke is the second leading cause of death worldwide and the third leading cause of adult disability in adults. Ischemic stroke triggers an inflammatory response in the brain that is cytotoxic. In response to ischemic stroke, T-cells from mobilize to the brain and modulate both cytotoxic and protective inflammation. Regulatory T (Treg)-cells exert a neuroprotective effect after ischemic stroke by inhibiting both inflammation and cytotoxic T-cell activation. Transplantation of bone marrow-derived stem cells (BMSCs) after ischemic stroke has a neuroprotective effect. One way that BMSCs protect neurons from apoptosis is by attenuating innate inflammation, but response of the adaptive immune system has not been well-studied. Our lab has found that implanted stem cells accumulate in locations with known importance to the adaptive immune system like the spleen. In this study, regulatory T-cells and BMSCs were shown to be neuroprotective following ischemic treatment of primary rat neurons.
Designing a Model to Explore Tau's Unfolded Protein ResponsePoster
The purpose of this research is to design a cell model in which ER stress caused by tau accumulation can be generated, and then investigated for changes in different ER stress-associated proteins.READ MORE
Extracorporeal shockwave therapy accelerates motor axon regeneration despite a phenotypically mismatched environmentPoster
A femoral nerve defect model was adapted for the evaluation of proregenerative effects of extracorporeal shockwave therapy (ESWT). Functional evaluation, histology and qRT-PCR data show differences between sensory and motor-derived nerve transplants and a pro-regenerative effect of ESWT. These data provide evidence for the clinical application of ESWT after autologous nerve transplantation as a novel non-invasive method.READ MORE