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Neurotoxicity Assays Using iPSC-Derived Neurons and High Content Imaging

Human neurons derived from induced pluripotent stem cells (iPSC), such as iCell® Neurons are very attractive for such studies because they exhibit functionality and behavior of mature neurons and are available in large quantities. Live cell assays can be automated with the ImageXpress® Micro system and MetaXpress® software to allow characterization of neurons and neuronal networks for health and extent of the network.

This poster presents examples of the use of these systems to study inhibition of neuronal development and neurotoxicity in assays that are well suited for screening of lead compounds and potentially important for reducing animal experimentation and cost of pre-clinical development.