Neurotoxicity Assays Using iPSC-Derived Neurons and High Content Imaging
Poster Oct 05, 2011
Oksana Sirenko, Susan DeLaura, Lucas Chase, Jayne Hesley and Evan F. Cromwell
Human neurons derived from induced pluripotent stem cells (iPSC), such as iCell® Neurons are very attractive for such studies because they exhibit functionality and behavior of mature neurons and are available in large quantities. Live cell assays can be automated with the ImageXpress® Micro system and MetaXpress® software to allow characterization of neurons and neuronal networks for health and extent of the network.
This poster presents examples of the use of these systems to study inhibition of neuronal development and neurotoxicity in assays that are well suited for screening of lead compounds and potentially important for reducing animal experimentation and cost of pre-clinical development.
CiPA Phase 2 Study: validation of an automated microelectrode array (MEA) assay of hiPSC-derived cardiomyocyte electrophysiology for cardiac safety evaluationPoster
These results support the use of hSC-CM and MEA technology for preclinical assessment of proarrhythmic risk within the proposed CiPA paradigm, and, more generally, demonstrate that automation of the CM-MEA assay can achieve high reliability and throughput for cardiac risk assessment in vitro.READ MORE
A luminescent solar concentrator-based photomicroreactor for energy efficient continuous-flow photocatalysisPoster
The Luminescent Solar ConcentratorPhotomicroreactor
(LSC-PM) is an innovative device
for solar-powered continuous-flow photochemistry.
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7th International Conference on Tissue Science and Regenerative Medicine
Oct 02 - Oct 04, 2017