New Platforms and Systems for DNA Microarrays
Introduction
DNA microarrays are commonly used in expression profiling and genetic analysis experiments. Today still many DNA arrays are based on short oligonucleotides or cDNAs. These can provide either high specificity or high sensitivity respectively, but cannot combine these qualities. Operon has designed probes of different lengths to various positions in the Open Reading Frames (ORFs) and the results clearly show that 70mers offer the optimal combination of specificity and sensitivity.
DNA microarrays are commonly used in expression profiling and genetic analysis experiments. Today still many DNA arrays are based on short oligonucleotides or cDNAs. These can provide either high specificity or high sensitivity respectively, but cannot combine these qualities. Operon has designed probes of different lengths to various positions in the Open Reading Frames (ORFs) and the results clearly show that 70mers offer the optimal combination of specificity and sensitivity.
