Novel Lewis Acid Catalyzed (E)/(Z)-Arylidene Thiohydantoin Formation
Poster Feb 21, 2006
Brian T. Gregg, Ph.D., William G. Earley, Ph.D, Kathryn C. Golden, John F. Quinn, Ph.D, Dana A. Razzano and W. Martin Rennells
In most examples, the Lewis acid promoted catalysis yielded reactions exhibiting increased reactivity, conversion and purity profiles as compared to the uncatalyzed reactions. Since arylidene thiohydantoins are reported in the literature as being biologically relevant moieties for antimicrobial, antiviral, immunosuppressive and potentially anticonvulsant indications, this validated protocol was then used as part of our parallel synthesis efforts to generate a library of approximately 400 target compounds.
New Biotransformation Prediction Engine Integrated into a Metabolite Identification SolutionPoster
Here we present a new prediction algorithm that determines the likelihood of biotransformation reactions, and subsequent metabolite identification, within an automated processing routine.READ MORE
NanoBRET™ Assays for Monitoring Protein Interactions in Living CellsPoster
NanoBRET PPI System is composed of two components.
NanoBRET offers improved S:B over other BRET assays.
NanoBRET provides sensitive live-cell method to study protein interactions.