Ocular papillary changes on the caruncle surface in allergic conjunctivitis
Poster Feb 21, 2015
Milton M. Hom, OD, FAAO1, Leslie E. O’Dell, OD, FAAO2, Carl J. May, Jr., MD2, Leonard Bielory, MD3
Rationale: The caruncle is located in the nasal corner of the eye and can be easily viewed. Prior reports have associated papillary changes on the caruncle surface as diagnostic sign of allergic conjunctivitis. We examined the caruncle and the rest of the palpebral conjunctiva under magnification and fluorescein dye to determine surface roughness in this multi-site, non-interventional, retrospective chart review.
Methods: Subjects over age 18 were viewed with a slit lamp and fluorescein dye under cobalt blue light with a yellow filter as part of routine eye examination. The caruncle was graded in 0.5 steps (0 smooth/normal to 4 severe papillary response). The palpebral conjunctiva was also examined and graded in the same manner.
Results: 285 consecutive patients were seen in two clinics. Significant differences were found between the caruncle and palpebral surfaces scores (p<.0000). The caruncle scores were consistently higher (mean 1.76 SD 0.82) than palpebral conjunctiva scores (mean 1.34 SD 0.74). Pearson correlation was 0.3 (p<.0000)
Conclusions: Greater papillae in the caruncle may indicate a greater inflammatory response when compared to the palpebral conjunctiva. This may explain why eye rubbing with allergic conjunctivitis is more likely to occur in the corner of the eyes where the caruncle is located. Allergists can examine the caruncle with the naked eye. Along with the location of eye rubbing, this can help to diagnose allergic conjunctivitis.
Characterization of a Type 2 diabetes-associated islet-specific enhancer cluster in STARD10 by genome editing of EndoC-βH1 cellsPoster
Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes. The majority of these are located in the intergenic or intragenic regions suggesting that the implicated variants may alter chromatin conformation. This, in turn, is likely to influence the expression of nearby or more remotely located genes to alter beta cell function. At present, however, detailed molecular and functional analyses are still lacking for most of these variants. We recently analysed one of these loci and mapped five causal variants in an islet-specific enhancer cluster within the STARD10 gene locus. Here, we aimed to understand how these causal variants influence b-cell function by alteration of the chromatin structure of enhancer clusterREAD MORE
Treatment Options for Chronic Parvovirus Viremia in Pediatric Heart Transplant Patients in a Tertiary Care CenterPoster
This abstract discusses three cases of pediatric heart transplant patients who suffered from parvovirus (B19) infection. Of these patients, two ( B & C) responded well to standard intravenous Ig therapy. Patient A however, did not respond to standard treatment and was begun on subcutaneous Ig, which effectively diminished his viral load. Thus, subcutaneous Ig infusions might serve as a second line treatment for transplant patients with parvovirus who do not respond well to the standard approach.READ MORE
T-helper cell phenotype expression in cutaneous lesions of angioimmunoblastic T-cell lymphomaPoster
Angioimmunoblastic T-cell lymphoma (AITL) is a common type of peripheral T-cell lymphoma. AITL can be missed until lymphadenopathy develops in patients initially presenting with skin lesions, as skin biopsy may lack conclusive findings. Our case highlights the extranodal presentation of AITL with cutaneous lesions displaying the TFH phenotype.READ MORE