Overcoming the Challenges of Analysing Ionic Polar Pesticides in Food
Poster Nov 03, 2017
Benjamin Wuyts, Euan Ross, Dimple Shah, Simon Hird, Gareth Cleland.
Glyphosate, a non-selective broad spectrum herbicide, accounts for more than half of global herbicide sales. While discussions on the toxicological concerns of glyphosate and associated compounds continue, maximum residue limits (MRLs) are enforced globally, requiring continued analytical testing to ensure consumer safety. In previous work, various methodologies have been presented, looking at underivatised options for the direct analysis of polar pesticides in food. [Scan the QR code below to discover more] Here, the novel application of the Waters’ Torus DEA column is presented, showing the improved performance of a UPLC-MS/MS method for the underivatised analysis of glyphosate and a selection of other anionic pesticides. Separation is achieved under Hydrophilic Interaction Chromatography (HILIC), after a simple column conditioning to activate the mechanism. Preliminary method performance, in the absence of isotopically labelled internal standard is summarised, in accordance with relevant SANTE 11945/2015 guidelines.
Automation of Sample Preparation for Metabolomic Analysis Using Robotic PlatformPoster
We developed an automated sample preparation protocol based on a robotic platform PAL RTC (CTC Analytics AG, Zwingen Switzerland), which represent a modified Bligh and Dyer method producing samples for both hydrophilic metabolomics using GC-MS and lipidomics using SFC-MS simultaneously.READ MORE
Mass Spectrometry: From Imaging to Metabolic NetworksPoster
We show that network analysis of co-localized ions from mass spectrometry imaging data provides a detailed chemo-spatial insight into the metabolic heterogeneity of tumor. Furthermore, module preservation analysis between colorectal cancer patients with and without metastatic recurrence suggests hypotheses on the nature of the different local metabolic pathways.READ MORE
Identifying Non-Intentionally Added Substances (NIAS) in Food Contact MaterialsPoster
Concern about the safety of food products has increased dramatically with intentionally and non-intentionally added substances (NIAS) used in packaging being of particular interest. APGC and high resolution MS together with a workflow driven process was used to identify unknown compounds in packaging.READ MORE