Performance of a hybrid gamma-optical camera for improved utility in diagnostic imaging
Poster Oct 06, 2014
L.K. Jambi1, J.E. Lees1, S.L. Bugby1, B.S. Bhatia1,2, M.S. Alqahtani1, W.R. McKnight1, A.H. Ng3 and A.C. Perkins3
The development of portable gamma cameras offers new applications for intraoperative imaging . Multi-modality systems have a long heritage in nuclear medicine . A multi-model gamma-optical system has been proposed as one possibility for improving surgical utility .
The Hybrid Compact Gamma Camera (HCGC) is novel handheld small field of view (SFOV) compact hybrid gamma-optical camera. The combination of an optical and a gamma-ray camera, in a co-aligned configuration, offers high spatial resolution scintigraphic imaging fused with anatomical information from an optical image. This study investigates the efficacy of the HCGC in intraoperative imaging in procedures such as sentinel lymph node biopsies.
The characteristics of the HCGC have been found to compare favourably with SFOV cameras currently in use. Spatial resolution of less than 1mm was recorded with a system sensitivity of up to 214cps/MBq. The effect of operator motion on spatial resolution was found to be less than 25%. Fused images showed good alignment of the two modalities allowing localization of activity.
The performance characteristics of a hybrid camera have been described and initial images demonstrate that it is ideally suited for intraoperative imaging. The anatomical context provided by the optical camera aids the physical localization of radiopharmaceutical uptake. These studies encourage us to carry out further evaluation in preparation for its use in a surgical theatre setting.
Human iPSC-derived cardiomyocytes: A translational model to predict drug-induced cardiac arrhythmias and long-term toxicityPoster
The results shown here imply that iPSC-derived Cor.4U human cardioymocytes are a translational in vitro cell model for the prediction of clinically relevant drug-induced cardiac arrhythmias and long-term toxicity.READ MORE
Fc Effector Bioassays for Rapid and Quantitative Measurement of ADCC and ADCP Mechanisms of ActionPoster
Drug developers are rapidly adopting Fc effector function reporter-based bioassays to measure antibody Fc functions such as ADCC and ADCP activity during the development of therapeutic antibodies. Here we show application of a suite of FcgR Reporter Bioassays to elucidate and characterize antibody MOA.READ MORE
Analysis of the Effect of Aggregated β-Amyloid on Cellular Signaling Pathways Critical for Memory in Alzheimer’s DiseasePoster
Here we evaluate the ability to detect changes in phosphorylation levels of ERK and CREB following treatment with Aβ using the SH-SY5Y neuroblastoma cell line.READ MORE
Comments | 0 ADD COMMENT
Like what you just read? You can find similar content on the communities below.Biopharma Cell Science Diagnostics Drug Discovery Informatics & Automation Proteomics & Metabolomics
To personalize the content you see on Technology Networks homepage, Log In or Subscribe for FreeLOGIN SUBSCRIBE FOR FREE