Population Characterization of Brazilian Isolates of Ceratocystis spp. Using Microsatellites
Poster Jan 12, 2015
Edson Luiz Furtado, Ana Carolina Firmino, Michael Mbenoun, Denise Nakada Nosaki, Ariska Van der Nest, Jolanda Roux, Irene Bernes, Mike Wingfield
Ten SSR markers developed previously were used and were polymorphic. These markers produced a total of 76 alleles for the 49 C. fimbriata isolates used in this study. Three distinct populations were identified using STRUCTURE and LNK analyses. Analysis of population differentiation show a Ө = 0.27 and p ≤ 0.04. High values of genotypic diversity were obtained for the combined (68.25%) and separate populations (77.77%, 52.08% and 100%). For the combined population, the Association Index (Ia) and baD values (Rd) were 1.91 and 0.22, respectively, indicating a high rate of recombination among the isolates.
Characterization of a Type 2 diabetes-associated islet-specific enhancer cluster in STARD10 by genome editing of EndoC-βH1 cellsPoster
Genome-wide association studies (GWAS) have identified more than 100 genetic loci associated with type 2 diabetes. The majority of these are located in the intergenic or intragenic regions suggesting that the implicated variants may alter chromatin conformation. This, in turn, is likely to influence the expression of nearby or more remotely located genes to alter beta cell function. At present, however, detailed molecular and functional analyses are still lacking for most of these variants. We recently analysed one of these loci and mapped five causal variants in an islet-specific enhancer cluster within the STARD10 gene locus. Here, we aimed to understand how these causal variants influence b-cell function by alteration of the chromatin structure of enhancer clusterREAD MORE
Psychiatric Risk Gene Cacna1c and Early Life Stress: Potential Gene-Environment interactions?Poster
Early life stress (ELS) is highly associated with development of psychopathology
and mood disorders in adulthood. Genetic studies have identified variation in the gene calcium voltage-gated channel subunit alpha1C (CACNA1C) to increase risk for several psychiatric disorders. This poster assessed the expression of Cacna1c following prepubertal stress.
Performance of the D5000 and High Sensitivity D5000 ScreenTape Assays for the 4200 TapeStation SystemPoster
Here, we focus on quantification, sizing, and sensitivity of both D5000 ScreenTape assays.READ MORE