Potential Benefits of Comprehensive Two=Dimensional Gas Chromatography — High Resolution Time-of-Flight Mass Spectrometry (GCxGC-HRTOFMS)
Poster Jun 06, 2014
Mark Merrick, Viatcheslav Artaev
GC×GC systems, both commercial and non-commercial, vary in performance. There are two key performance characteristics that determine the performance of a GC×GC system—injection peak width and modulation speed. For typical column configurations (30–60 m first column) an injection peak width with <10 ms and a modulation period as short as 1 second are required. If either of these are less than optimal, the peak capacity and resolution in the first and second dimensions will be compromised. To obtain the best results from a high performance GC×GC system, the detector must be capable of high data acquisition rates. For a typical GC×GC column configuration, a data acquisition rate of approximately 200 spectra/s is required. Slower detectors are used with sub-optimal GC×GC systems and/or sub-optimal column sets and conditions to match the peak width with the data acquisition rate. GC×GC-TOFMS with nominal mass resolution has demonstrated its high performance in various application areas over the past several years and is considered one of the most powerful techniques for targeted and non-targeted analysis of complex volatile and semi-volatile mixtures.
High resolution mass spectrometry is well-known for its increased selectivity. This poster presents preliminary data for a sewage treatment plant water extract collected on a research prototype GC×GC-HRTOFMS and compares the results of a selected region to those obtained by GC-HRTOFMS.