Preparation of Photonic Biosensors by Inkjet Printing Technology
Poster Oct 28, 2016
F. Strassera, c, E. Melnika, R. Heera, P. Muellnera, G. Mutinatia, R. Hainbergera , J. Kraftb, G. Meinhardtb, J. Siegertb, P. Lieberzeitc
In order to enable local functionalization of label-free optical waveguide biosensors in a cost effective mass-fabrication compatible manner, we investigate surface modification employing inkjet printing of a) functional polymers (biotin-modified polyethylenimine (PEIB)) to implement high receptor densities at the surface and b) UV-curable benzophenone dextran (benzo-dextran) to form a voluminous porous hydrogel matrix. The combination of these approaches on a single chip is promising for the detection of biomolecules. We evaluate these functional polymers and hydrogels on an integrated four-channel silicon nitride (Si3N4) waveguide based Mach-Zehnder interferometric (MZI) sensor platform operating at a wavelength of 850nm (TM-mode).
Sample preparation is a key step in the analysis process
Parameters for evaporation and their impact on analysis have been discussed
Improvements in matching the sample to the evaporation device characteristics can help reduce variability and improve recovery
Examples for choosing a system based on sample volume, types of analytes, sample load, and initial investment considerations