Reporter Bioassays to Assess Therapeutic Antibodies for Immunotherapy Programs
Poster Oct 09, 2015
Mei Cong, Zhi-Jie Jey Cheng, Pete Stecha, Jun Wang, Jamison Grailer, Natasha Karassina, Jim Hartnett, and Frank Fan
Immunotherapy, also called biologic therapy or biotherapy, stimulates certain parts of the immune system to fight diseases such as cancer. Important drug targets in immunotherapy include: Co-inhibitory receptors, such as PD-1/PD-L1, CTLA-4, LAG3, Tim3; and co-stimulatory receptors, such as GITR, CD40, OX40, 4-1BB.
Current approaches to assaying these targets are cumbersome and variable. Here we offer an improved in vitro bioassay approach.
Nitrogen metabolism in Mycobacterium tuberculosis: a systems-based approachPoster
Previous studies suggested that Mycobacterium tuberculosis obtains nitrogen from a diverse range of intracellular nutrients including amino acids. Here, we use a novel system’s based three-pronged approach to define pathways for uptake and assimilation of nitrogen.READ MORE
Cerebral Malaria Insights: Pathogenesis, Host Parasite Interactions including Host ResistancePoster
Cerebral malaria is a dreadful disease transmitted by mosquito. The major preventive approach is focused more in vector control than development of anti-malarial drug. The purpose of this presentation is to analyze different aspects of disease manifestations including clinical symptoms and pathogenesis in the context of mosquito borne infections in different geographical regions of the world.READ MORE
Amoebic Meningoencephalitis: Etiology, Infection and PreventionPoster
The presentation covers the different types of organisms that can cause amoebic meningioencephalitis. The two main types focused on are primary amoebic meningioencephalitis and granulomatous amoebic meningioencephalitis. The method of transmission and target hosts are vastly different. Prevention of these diseases is imperfect at best, as complete avoidance is the only way to not contract the disease.READ MORE
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2nd International Conference and Exhibition on Nanomedicine and Drug Delivery
May 21 - May 23, 2018