Reporter Bioassays to Assess Therapeutic Antibodies for Immunotherapy Programs
Published: October 9, 2015
Immunotherapy, also called biologic therapy or biotherapy, stimulates certain parts of the immune system to fight diseases such as cancer. Important drug targets in immunotherapy include: Co-inhibitory receptors, such as PD-1/PD-L1, CTLA-4, LAG3, Tim3; and co-stimulatory receptors, such as GITR, CD40, OX40, 4-1BB. Current approaches to assaying these targets are cumbersome and variable. Here we offer an improved in vitro bioassay approach.