We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
Response to ragweed allergen provocation in the Red Maple Trials Allergen Challenge TheatreTM
Poster

Response to ragweed allergen provocation in the Red Maple Trials Allergen Challenge TheatreTM

Response to ragweed allergen provocation in the Red Maple Trials Allergen Challenge TheatreTM
Poster

Response to ragweed allergen provocation in the Red Maple Trials Allergen Challenge TheatreTM

Rationale: Allergen challenge chambers expose allergen-sensitive subjects to a predetermined concentration of allergen in a closed, controlled environment and provide a mechanism to induce clinical symptoms and measure the effect of medication.
Methods: We evaluated the response of ragweed-allergic subjects to two ragweed challenges in the Red Maple Trials Allergen Challenge Theatre. A provincial Ethics Board approved the study. After signing informed consent, patients with a history of ragweed allergy, not on allergy medications and with a positive skin prick test to ragweed antigen (> 3 mm) were exposed to ragweed pollen in a 3-hour priming session. Total nasal (TNSS), ocular and respiratory symptom scores (TRSS) were recorded at baseline and every 30 minutes during the challenge. Those with a TNSS > were then selected for 2 further 4-hour challenges.
Results: 48/76 subjects evaluated underwent the priming challenge. Thirty-three subjects achieving a peak TNSS ≥5 were selected for two subsequent 4-hour challenges. Baseline TNSS (mean± SD) was 1.70 ±1.34 and 2.53±1.76 in challenges 1 and 2, respectively. Baseline TRSS values were 2.00± 1.66 and 3.60±2.69 respectively. Symptom scores reached a plateau by 120 minutes and remained steady for the remainder of the 240-minute exposure period. Plateau TNSS was 6.28±0.20 for Challenge 1and 6.19±0.24 for Challenge 2. Similarly, TRSS values were 9.10±0.20 and 9.11± 0.33, respectively.
Conclusions: The Red Maple Trials allergen exposure theatre demonstrated the capacity to induce symptoms of appropriate intensity upon allergen challenge. Our chamber with a seating capacity of 100 places has the ability to evaluate large test groups at a time.
Advertisement